The story is that of Gary Hampton, a wealthy CEO of a record company who is mauled by a werewolf while on a family vacation.

The story revolves around Gary's efforts to control his animalistic instincts and use his powers for good and to be a superhero, despite being plagued by a curse.

Although Wolf-Man's own series was concluded and all loose ends tied up, Kirkman pointed out that characters from Wolf-Man's universe would still crossover into his other characters' lives as they inhabit the same universe;[1] Wolf-Man himself appeared in the Invincible series several times, notably in a two-part storyline (Invincible Universe #8–9) sent as part of an extraction squad consisting of Popper, Mantis, Best Tiger, and Claire Voyant to capture a Brazilian super-criminal known as Redeye.

As the prisoners and townspeople, left bloodthirsty following Redeye's depowerment, Wolf-Man, still weak, is unable to stop the riot and becomes separated from Davi.

Fearing he has again failed to save a child, Wolf-Man returns to the base unaware that Davi has escaped harm and now possesses Redeye's powers.