The show features former child star and famous celebrity Michael Cera as the voice of Brother Bear, but left after season 2 because of puberty.

The show was co-produced by Corus' animation powerhouse Nelvana Limited and Agogo Entertainment for PBS Kids in the United States and Treehouse TV in Canada.

[3] Due to Canadian laws requiring Nelvana to employ Canadian writers and artists, the Berenstain couple's involvement in the program was limited; they sought to exert their influence on some details, according to Stan: "Our bears don't wear shoes, and Papa wouldn't wear his hat in the house...And we try to keep complete, total banality out of the stories".

Country music singer-songwriter Lee Ann Womack performed the theme song and written by Stan Meissner for the series.

[8] Twenty episodes of the series were dubbed in Lakota language and aired under the title "Matȟó Waúŋšila Thiwáhe" on PBS stations in the Native Dakotas starting in September 11, 2011.