The Big Bust Out is the US title of an Italian women in prison film, The Crucified Girls of San Ramon (Io Monaca... per tre Carogne e Sette Peccatrici).

After the breakout, Rebecca (Karen Carter) and her fellow escapees find they are in more trouble than they had imagined as they become the victims of Miller Drake (Gordon Mitchell), who is involved in white slavery.

She is currently taking care of the souls of a number of "sinners" (as the Italian film title euphemistically suggests), all convicts who are quite tough and hard-nosed, but who are regularly bullied and beaten, humiliated and sexually abused by their guards.

Desperate to improve the living conditions of the girls, Maria appeals to the prison warden to allow seven of these women to work during the day under the supervision of guards (and God's) in the nearby convent.

The unscrupulous Bob plans to sell the women, including the nun Maria, to a sheikh named El Kadir.

Jeff is temporarily sidelined, leaving the women and the nun to finally surrender to the filthy, drooling Kadir people.