The Big Sister is a lost[1] 1916 American drama silent film directed by John B. O'Brien and written by Harvey F. Thew.

The film stars Mae Murray, Matty Roubert, Harry C. Browne, Ida Darling, Armand Cortes and Tammany Young.

[2][3] Escaping Nifty Mendez, a slave trader who framed their father, Betty Norton and younger brother Jimmy are on the run when the boy is hit by a car that fractures his leg.

The driver, Rodney Channing, insists on hosting Jimmy during his convalescence and so, dating the beautiful Betty, he falls in love with her and the couple begin to plan a future together.

But Mendez, having learned of the thing, threatens the girl, whose father is in prison: if he does not pay for her silence, he will reveal her past to the betrothed, thus messing up the wedding.