[1] 220 Bowery was designed by architect Jacob Fisher and built in 1924 in the Colonial Revival style after the property purchased by L Cohen & Sons that same year as a 4-story brick with stores on the ground floor and hotel.

By the 1940s, in an era when the Bowery was known as New York City's "Skid Row," the hotel had been transformed to accommodate returning soldiers from World War II, down-and-outs and the down-on-their-luck as a flophouse.

While these rooms were meant to be temporary lodging, guests of The Prince Hotel could indulge in all of the vices that the neighborhood provided and many of its occupants stayed on for extended periods of time.

In 2000, Click modeling agency co-owner Joey Grill, purchased the building under AHJ Corporation for $2.2 million to create luxury lofts.

[8][7][9] In 2011, The Bowery House opened its doors after its redevelopment by Italian race car driver Alessandro Zampedri and American real estate entrepreneur Sanford Kunkel.