[15] The hospital originally consisted of 5 floors and 125,000 square feet of space and 68 patient beds.

[17] In 2004 a partnership between Morgan Stanley Children's Hospital of NewYork-Presbyterian and BMSCH to help with the creation of a pediatric heart surgery and cardiology program.

[21][22] In 2007, Bristol Myers Squibb Children's Hospital at RWJUH was joined by the PSE&G Children's Specialized Hospital and the Child Health Institute of New Jersey (RWJMS) to create the first pediatric medical campus in New Jersey, with pediatric acute care, rehabilitation, and research were combined on one campus.

In 2013, Bristol-Myers Squibb Children's Hospital opened up a new $11.5 million, 17,000 square foot facility named "The Center for Advanced Pediatric Surgery.

[34][35] After the 2018 bankruptcy of Toys-r-us, liquidation sales were handled by attorney Joseph Malfitano who wanted to see the 16-foot-tall Geoffrey the Giraffe statue go to a children's hospital.

[36] He contacted the BMSCH who accepted the statue for their lobby, with Malfitano covering the $10,000 shipping cost.

[40] The renovation created a space where pediatric patients aged 0–21 could be separate from adults that require treatment.

[44] The hospital features an AAP verified level 3 neonatal intensive care unit, one of the highest in New Jersey.

[54] The house provides places to sleep, meals, and entertainment to siblings and families for free.