It centers on five humanoids, named Frank, Tony, Bing, Dean and Sammy, who are in search of their lost brother Perry.

[2] The series had a short run and was met with a generally negative reception, with many considering it one of the worst animated TV shows ever made.

[3] The series centered on an ensemble cast of pale, rubbery, twitchy, yellow-eyed, blue-haired, green-tongued and shirtless humanoids called "The Brothers Grunt" or simply "The Grunts" with prominent bulging varicose veins, generally clumsy and dim-witted, able to bend, twist and contort their bodies into various forms, all of them ostensibly male, wandering around in their signature attire of boxers and wingtip shoes.

A group is formed, composed of five of a group of sextuplets born from the Maximus in a rare occurrence, in a quest to bring back their sixth brother, Perry, who has abandoned his involuntary position of "Chosen One" (leader of their order) and is now living the "high life" among human beings (who seem to deal with the bizarre nature of the Grunts by ignoring them and pretending everything is normal).

Not much is known about the Grunt religion (itself seemingly a spoof on Catholicism due to the brown monk's habit worn by the brothers on occasion) other than that it involves the almost monomaniacal reverence, production and eating of cheese, as well as a variety of bizarre rituals overseen by the Gruntus Poobah.

A sporting event is held on occasion called the Grunt Games, as shown in the episode of the same name, including such sports as necktie-folding, sumo, doing a clean and jerk using a giant cheese called the Great Dane before swallowing it whole, diving off the Maximus into a pool of melted cheese, throwing a giant olive into a sandwich, and a relay race involving assembling a martini.

The main characters were named after famous crooners of the 1950s: Frank (Sinatra), Tony (Bennett), Bing (Crosby), Dean (Martin), Sammy (Davis Jr.), and Perry (Como), all voiced by Doug Parker.

Although Danny enjoyed the success of Lupo The Butcher, he wanted to leave International Rocketship Ltd. and start his own animation company.

Kenneth R. Clark of the Chicago Tribune said that, with the series, MTV "created the most repulsive creatures ever to show up on a television screen" and "accomplished the seemingly impossible.

"[13] Charles Solomon of the Los Angeles Times called the show "an effortful, sophomoric half-hour that leaves the viewer longing for the refined good taste of Alice Cooper.