The series starred Malcolm Stoddard as James Campbell, a Scottish doctor living in 1830s Upper Canada with his three children, seventeen-year-old Neil (John Wildman), fourteen-year old Emma (Amber-Lea Weston) and eleven-year-old John (Eric Richards).

[1] Dr. James Campbell, a widower with three children, treated the broken leg of the son of a wealthy landowner but, after a servant woman applied unsterile home remedies to the leg, the boy died of infection.

[9] Most of the episodes were shot on location at a 50-acre farm owned by the Ontario Heritage Foundation,[4] and all clothing, furnishings, and the doctor's medical treatments, were historically accurate.

[10] In 1996 GoodTimes Entertainment released a two volume VHS set of selected episodes entitled Adventures On the Prairie With The Campbells.

[11] On June 23, 2015, Timeless Media Group released The Campbells - The Complete Series on DVD in Region 1.