Popular band The Magic Numbers attended Cardinal Wiseman, as well as Jason Roberts, former Premier League striker for Blackburn Rovers and Reading.

[3] Also, the professional football player Aaron Pierre, who plays defender for Wycombe Wanderers attended Cardinal Wiseman.

Power metal band DragonForce's keyboardist Vadim Pruzhanov attended Cardinal Wiseman.

Young actor James Forde, who plays Liam Butcher in the soap EastEnders attended the school.

An article in The Independent in November 2014 by former pupil Kris Griffiths highlighted the famous alumni produced by Cardinal Wiseman during a difficult time for the school, following a stabbing.