She aimed to surpass her previous work, Pandora Hearts, by drawing more appealing fight scenes and focusing more on the themes involving hidden identities.

For her next work after the manga Pandora Hearts, Jun Mochizuki wanted to draw vampires in a high school setting.

While sightseeing in Mont Saint-Michel, she mused about drawing the story of a single vampire who had watched over an island for about a hundred years.

[3] The usage of a steampunk setting was done because the author has been a fan of it for a long time and wanted a contrast with her previous work.

When she watched it, she was captivated by the tragic and fleeting existence of vampires, as well as the blood-sucking scenes, so those ideas were planted firmly in the author's mind.

Additionally, it had an effect on her fondness for stories with a dynamic between a young man and a girl, which influenced her handling of the protagonists.

In the storyboard phase, which serves as the "blueprint" for the finished video, Itamura wanted to represent as many of the poses from the manga as possible.

[5] Itamura said it was difficult to make a general distinction, but he thinks that "shojo manga-like" elements occupy a large part of the series.

[5] The protagonists Vanitas and Noé are voiced by Natsuki Hanae and Kaito Ishikawa, respectively, and their performances were the subject of positive response.

Hanae makes full use of all the cool, uncool, and sexy parts to bring out the charm of Vanitas whereas Ishikawa is good at playing the reaction of natural's boke's.

Hanae was cast as Vanitas for his vast experience as an actor and also because of the sex appeal he can bring even when reading simple lines like "It's a secret".

In addition, it allowed her to strike a balance with Noé, the other main character, who is pure, kind, and has a strong sense of justice and responsibility.

[7] Then in terms of the idea of the real name of vampires, she thinks in video games and anime and fantasy manga in Japan is a concept that is used quite often, so it's not a "novelty" created by her.

Upon first seeing it, writer Deko Akao believed that such item appears to have a history, something which proved him right upon further seeing Vanitas' past in the manga.

[8] Anime News Network stated that such earrings reflected his mortality and short lifespan which also comes across as the message the author aims to give.

[9][10] Written and illustrated by Jun Mochizuki, The Case Study of Vanitas started in Square Enix's Monthly Gangan Joker on December 22, 2015.

[11][12] In April 2020, Mochizuki announced that the manga would be on hiatus due to the COVID-19 pandemic;[13] it resumed publication in November of the same year.

[17] On December 3, 2015, Yen Press announced on its official Twitter account that it would be publishing new chapters of the series concurrently with Japan.

It was directed by Tomoyuki Itamura, with scripts overseen by Deko Akao and character designs by Yoshiyuki Ito.

[48] The focus on romance between arcs was praised for its handling of Vanitas as hilarious character considering how poorly he reacts to his feelings towards Jeanne.

[53] Manga News enjoyed the multiple character designs, spanning from bishonen types to built bodies who interact together.

[55] The Fandom Post claimed the art was "stunning", praising the details of every page, including the fight sequences.

[66][67] The massive violence displayed in the series' fifth episode resulted in Funimation warning sensitive viewers to avoid watching it.

[68] Bones' animation has been generally praised for making the settings and character details appealing alongside Yuki Kajiura's music.

[70] The Fandom Post noted that Vanitas and Jeanne's comical date is more enjoyable than the main plot which is later foreshadowed.