The remainder of the former Dominion space was initially occupied by a home video rental business (Jumbo Video, which closed after a couple of years), then after 1992 by Pinder's Drugs (later Shopper's Drug Mart; after Shopper's purchased the Pinder's chain there was a period of about a year during which two SDM locations were adjacent to each other, due to there already being one in Circle Park Mall).

In the summer of 2004 a new Walmart had started construction in nearby Preston Crossing several kilometres North from Centre Mall.

The older Zellers outlet was vacant but left open to foot traffic for the Safeway store (now Co-op) before it was demolished and re-built as a Best Buy in autumn of 2010.

In 2016 the west quarter portion of the Target was renovated with an Ardene women's clothing outlet taking its place.

As part of this renovation, the Canada Safeway, which was previously accessed through Zellers, was converted into a standalone store, no longer joined physically to the mall.

Around this time a standalone block of shops including a branch of Indigo Books and Music was constructed along the north side of the property; although not physically connected to the rest of the mall, these retailers are considered part of The Centre.

[8] In 2019, renovation work began in Centre East (including the tunnel connection under Acadia Drive) in preparation for redevelopment of the soon-to-be-vacated theatres.