It was released on 14 September 1999 as the lead single from the band's third album The Science of Things (1999).

He said, "I was thinking the chemicals between us would be when things aren't going so good and you're in that lonely bed with that person and you're not communicating.

"[3] The song is unique among most other singles by the band due to its numerous electronic elements as well as an almost dancey percussion.

Later, the scene becomes interspersed with Rossdale doing karate blindfolded and Parsons doing martial arts as well.

Alternative Songs chart and peaked on the Billboard Hot 100 at number 67 on 4 December 1999.