The first complete hospital building was erected on William Avenue at Sherbrook Street and opened on December 2, 1956.

To raise funds, a successful fundraising campaign begun in 1948, headed by prominent businessman John Draper Perrin.

Used books were gathered early in the spring, to be sold at the market in May at Polo Park Shopping Centre.

Said Mr. Robinson at the announcement:When this hospital was built, it was expected to become a straight community-type treatment institution with a minimum of services to take care of the run-of-the-mill conditions that have to be treated in the community.

X-ray facilities, laboratories, emergency space, out-patients' department and special therapy provisions had been kept at an absolute minimum.

In the 60 years of its operation, 817 pediatric nurses graduated, later working in other parts of Canada and the United States.

[10] Today children staying at the Hospital have more entertainment options such as YTV, Teletoon, videogames, YouTube (via tablet or smartphone), so there is less need for CHTV.

Today the hospital has an emergency department for children and has pediatric and neo-natal intensive care units.

This department of specialists is involved in running the playroom, the in-hospital television station (CHTV),[12] provided for free, now on channel 7.

This department exists to help children and their families cope with all aspects of illness and hospitalization by relieving stress and anxiety.

[14] Tommy Douglas, the Father of Medicare in Canada, in an interview attributed the efforts of the Children's Hospital of Winnipeg and the "very famous orthopedic surgeon Dr. R. J. Smith" for saving his leg at age 10.