He finds an ocean liner beached in the Gulf of Mexico, and determines to fix it and sail to a safe island to save some portion of humanity.
Lucius Greer has been keeping Amy and Carter alive in the cargo hold of their own ship, the Chevron Mariner, by bringing them blood to feed on.
He accepts a request from the newly-elected president of the Republic of Texas to join her administration in leading an initiative to open the town's security gates—since the virals have not been seen for years—and allow humanity to branch out.
After Liz died, Tim eventually joined Jonas in his research to find a solution to humanity's challenge (resulting in Amy).
The rest of his story is chronicled in the beginning of The Passage: Tim is the only one of the Twelve to survive the initial infection and thus becomes the first viral (Subject Zero).
Alicia leaves to warn her friends, while Zero sends his Many (infected virals) towards Texas in a plan to draw Amy out of hiding.
Virals Alicia and Amy are joined by Peter and Michael, leaving the ship to find and kill Zero in New York City, in order to end the plague.
After 1000 years (which is said to be the minimum required time for the virals to die off on their own in case they would not be stopped), their descendants return to North America.