The Cleaning Lady centers on Thony De La Rosa, a Cambodian-Filipino former surgeon who is currently working and living in Las Vegas.

She is in the US on an expired visa with her five-year-old son Luca, who has a rare and life-threatening medical disorder for which he needs a cutting-edge bone marrow treatment, which is only available in Las Vegas.

As a result, Thony begins living a double life, keeping secrets from her family, while cleaning up crime scenes and evading the law.

[50] On February 1, 2023, Fox renewed the series for a third season, and Jeannine Renshaw joined as an executive producer and co-showrunner.

[53] In March 2020, Shannyn Sossamon, Adan Canto, Ginger Gonzaga, and Vincent Piazza were cast in main roles for the pilot.

[8] In December 2023, Kate del Castillo, Santiago Cabrera, and Clayton Cardenas were cast as new series regulars for the third season.

[6][65] The same month, Jacqueline Obradors and Jason Manuel Olazabal joined the cast in recurring roles for the third season.

[9] On November 11, 2024, Yancey Arias joined the cast in a recurring role, while Khalen Roman Sanchez came onboard as a new series regular in a recasting, replacing the LaSalle twins for the fourth season.

[11] The pilot originally started filming on March 10, 2020, in New Mexico,[57] but production was suspended three days later due to the COVID-19 pandemic.

The website's critics consensus reads, "Elodie Yung is winning as a resourceful protagonist in over her head, but The Cleaning Lady needs to polish its clichés into something more substantial if it wants to truly sparkle.