The musical made its world premiere at the Southwark Playhouse on 15 May 2019 for a limited run until 8 June.

The cast included James Marlowe in the titular role, alongside Matt Burns, Rosalind Ford, Joey Hickman, and Philippa Hogg.

The expanded cast included Matthew Burns, Jonathan Charles, Oonagh Cox, Anna Fordham, Philippa Hogg, Damien James, Ann Marcuson, Molly Osborne, Jamie Parker, Jack Quarton, Benedict Salter and Tonny Shim.

John Dagleish plays Benjamin Button with Clare Foster as Eloween Keene, and the production features the majority of the 2023 Southwark Playhouse supporting cast.

[4][5] The musical takes place at the end of World War I in a small Cornwall fishing village and follows Benjamin Button as he lives through the twentieth century.