Based on the short story "The Colour Out of Space" by H. P. Lovecraft, it tells about a meteorite that crashes into a farming community in Tennessee, and infects the land and its residents.

[3] Trans World Entertainment and its successor company Epic Pictures used the Curse name for three more Italian-made horror films that they distributed in the U.S., although they were narratively unrelated.

Teenage boy Zack lives on a farm in Tellico Plains, Tennessee with his mother Frances, younger sister Alice, stern and pious old stepfather Nathan Crane and unpleasant, dim-witted stepbrother Cyrus.

One night Frances sneaks out of the house while Nathan is asleep and begins having sex with Mike, a farm-hand who lives in a nearby shack.

Next morning, Alan Forbes, a physician who lives nearby, visits the crash-site, examining the meteorite which is a large sphere with a hard shell from which a noxious liquid oozes out.

Believing the blight affecting his farm to be a punishment from God for his wife's infidelity, Nathan locks her in their bedroom, not allowing Zack to tell the doctor.

Carl Willis, a TVA representative who is surveying the local area for the planned reservoir, enters the Cranes' house looking for a glass of water.

Worried that Forbes is going to alert the authorities, Davidson and Esther arrive at the Crane farm looking for the doctor but are attacked by infected dogs who have turned feral.

A guilt-ridden Forbes enters the house, hoping to rescue Zack and Alice but he is surprised and murdered by Nathan who then barricades the door.

Some months later, a heavily-bandaged Willis lies in a hospital bed, having become infected more slowly because he only drank a small amount of the farm's water.

Later, at a location in the nearby countryside, ground and trees begin to heave and break apart at night, revealing more of the glowing alien liquid spreading onto the surface.

A large amount of the substance appears, suggesting that the hostile mutagenic entity is still alive, planning to complete its invasion of Earth.

David Keith was originally hired to star in Trans World Entertainment's The Further Adventures of Tennessee Buck, which was scheduled before this film.

[5] Trans World was originally looking for a farm in the vicinity of Los Angeles, but when Keith signed on as a director, he offered to relocate the production to a property he had just purchased in his native region of East Tennessee, which was accepted.

Kathleen Jordan Gregory, who made her feature debut, and Steve Carlisle were members of the Clarence Brown Theatre troupe alongside Keith.

[10] The director, a country singer in his spare time, also hired two musician friends, John Schneider and, in a cameo, T. Graham Brown.

He has accused the producers of overworking him in violation of child labor laws, crew members of touching him inappropriately, and the director of being under the influence of drugs.

[3] However, comments by Amy Wheaton and mother Debbie to the Knoxville News Sentinel shortly after that scene paint a much less dramatic situation than the one described by her brother.

"[28] Michael Wilmington of the Los Angeles Times appreciated the parallels between the locals' unwillingness to confront the infection and the hypocrisy of small town conservatism, and noted that the "actors are good, especially Akins and Malcolm Danare".

"[29] Robert Trussel of The Kansas City Star partially disagreed, finding that Keith "clearly directs for laughs" but still showed "an uncertain grasp of the material".

Micalizzi's work was released by Italian label GDM Music on June 28, 2011, on a limited edition CD that includes a suite from Black Demons as a bonus track.