Aided by A. Stamatis, the CEO of the Bank of Cyprus Oncology Center worked with a team of scholars, where they undertook the coordination, research, and planning of the institute.

The vision of the institute and its staged development spanning a ten-year period was presented, debated, and endorsed by a convocation of international scholars held in Nicosia in June 2002.

The convocation was chaired by Hubert Curien, former minister of research of France, who accepted the founding chairmanship of the CREF Board.

[15] The Board is chaired by Didier Roux, a French physicochemist, Director of research and innovation at Saint-Gobain and a member of the French Academy of sciences and the Academy of Technology, and includes world-renowned academics, all living presidents of the republic, regional and international political, civic and business leaders.

The center focuses on advancing scientific technologies in the fields of Archaeology and Cultural Heritage, particularly in the Mediterranean-Middle East region.

The center is actively involved in research projects relating to improve the computing infrastructure of the Eastern Mediterranean region.

Initial activities of the center are large-scale climate modeling, the analysis of the data generated by the SESAME synchrotron facility in Jordan, and the detailed storage and visualization of archaeological cultural information.

CARE-C is focused on addressing urgent climate change and air pollution challenges and impacts in the EMME region.