[7][8][9] Kelvin Droegemeier, an atmospheric scientist who previously served as the vice president of research at the University of Oklahoma, was nominated for the position on August 1, 2018[10] and confirmed by the Senate on January 2, 2019.

Michael Kratsios was nominated by President Trump to be the fourth Chief Technology Officer of the United States and associate director of OSTP in March 2019[11] and was unanimously confirmed by the Senate on August 1, 2019.

President Joe Biden named, and the Senate later unanimously confirmed,[13] Eric Lander as head of the Office of Science and Technology Policy, while also upgrading the position to a cabinet-level post.

It is the first time that the White House has recognized scientists who study the climate denial operation run by the fossil fuel industry.

[16] On August 8, 2022, President Joe Biden signed into law the CHIPS and Science Act which included a provision to create a blockchain and cryptocurrency specialist advisory position under the OSTP to be established and appointed by the Director.