The film features Joseph Fiennes, Winona Ryder, David Arquette, Juliette Lewis, Wilmer Valderrama, Chris Penn, Julianna Margulies, Robin Tunney, Lawrence Ferlinghetti, Brad Hunt, Adam Savage, Jamie Hyneman and Metallica.

The film includes several full and partial re-enactments of "Darwin Awards", the earliest of which were fictitious, most notably the debunked JATO Rocket Car story.

Fired from the police force after his hematophobia allows a serial killer to get away, Michael wallows in a deep depression for several weeks before coming up with a way to combine his Darwin Awards obsession with his talent for profiling.

Siri and Michael travel the country on behalf of the company, investigating several legendary examples of stupidity, such as the JATO rocket car.

A twist of fate leads to Michael discovering where the murder suspect he originally allowed to escape now lives, as he videotapes the man in his home by rappelling down the side of the building.