The show depicts the life of Molly Bickford Dodd, a divorced woman in New York City with a lifestyle that could be described as both yuppie and bohemian.
The BBC's Radio Times characterised the show as "An American comedy-drama series starring Blair Brown intelligent, attractive and independent, Molly Dodd has the world at her feet—so why must it always trip her up?
The Days and Nights of Molly Dodd had story lines that often did not resolve in a single episode.
After its NBC cancelation, cable network Lifetime picked up the series, first re-airing the 26 episodes originally produced, and then commissioning three more 13-episode seasons for 1989, 1990, and 1991.
Brown won a CableACE Award for Best Actress in a Dramatic Series in 1991, during the fifth and final season's airing.
Despite some demand for the show on DVD or streaming services, the original producers did not clear music rights for subsequent broadcast.