[3] A six-episode sequel anime series entitled The Disastrous Life of Saiki K.: Reawakened premiered on Netflix in December 2019.

Kusuo Saiki is a high school student with an extraordinary secret—he possesses a wide array of psychic abilities, such as psychokinesis and teleportation.

Despite his powers, he goes to great lengths to conceal them from everyone at school, desiring to live a normal, average life.

Throughout the series, Kusuo usually finds himself in comedic daily life scenarios where he discreetly employs his powers to navigate the challenges he faces.

Despite this, he regains his abilities and learns that he is basically a different species of human now, as his body has adapted to his overwhelming powers.

A flash anime series based on the manga began release on Jump Live from August 4, 2013, featuring the same voice cast as an earlier Comic adaptation.

J.C.Staff and Egg Firm produced the adaptation, with Hiroaki Sakurai directing, Michiko Yokote handling series composition and Masayuki Onji designing the characters.

[19] The opening themes are "Seishun wa Zankoku janai" (青春は残酷じゃない, Youth Isn't So Cruel) by Natsuki Hanae, "Sai-Sai-Saikōchō!"

[24] On March 24, 2019, it was announced that a new anime series would be released on Netflix, with the cast and staff returning to reprise their roles.

[32] Kusuo also appears as a playable character in the Jump crossover fighting game J-Stars Victory VS released in 2014.