The Doctor's Wife, known in Japanese as Hanaoka Seishū's Wife (華岡青洲の妻, Hanaoka Seishū no tsuma), is a noted novel by Sawako Ariyoshi written in 1966.

The partly historical novel is based on the life of noted male physician Hanaoka Seishū.

Though much is based on fact, many events were added for dramatic purposes.

The novel follows the protagonist, here named Kae, from youth until death.

From there Kae learns that Otsugi is not the angelic beauty she outwardly displays and they both compete for the affections of Seishū, who is experimenting on animals to develop an anesthetic for surgery.