Jon Stashower was the SportsCenter anchor for the show in the 8pm-11pm slot until 2008, when he was moved to the afternoon spot allowing anchors Marc Kestecher and Neil Jackson to split the time between 8pm–11pm.

The debuting of The Doug Gottlieb Show, caused a major shake up in the ESPN Radio lineup, as SportsNation on ESPN Radio was dropped completely from the airwaves and The Brian Kenny Show was created to take up the later slot, from 8pm-10pm.

Since joining ESPN Radio in September 2003, Gottlieb had co-hosted GameNight along with personalities such as Chuck Wilson, Jeff Rickard, John Seibel and Freddie Coleman.

Due to Gottlieb's extensive work for ESPN's college basketball coverage, the primary fill-in host for the program during the evening was Andy Gresh but since Gresh's departure from ESPN Radio, Jason Smith was the regular substitute for Gottlieb.

On July 31, 2012 it was announced that Gottlieb had signed with CBS and would no longer be appearing on ESPN.