The series stars Andrew Sabiston and Marnie McPhail as fraternal twins Tom and Annie Edison, Sunny Besen Thrasher as their mischievous little brother Paul, and Milan Cheylov as their bumbling friend Lance Howard.

Brian George stars as their police officer friend Sgt.

The show focused on the adventures of the main cast as they stumbled onto one problem after another, using Tom and Annie's scientific wit to solve the situation.

In later seasons, Corey Haim joined the shows as recurring character Larry.

[2] Many episodes end with a short animated sequence illustrating a key scientific principle demonstrated in the preceding live action story.