The Empire of Corpses (屍者の帝国, Shisha no Teikoku) is a 2015 Japanese science fiction adventure horror anime film produced by Wit Studio and directed by Ryoutarou Makihara.
When Waston refuses to accept that it was a part of Frankenstein's original research, Karamazov commits suicide by having the corpsified Nikolai forcibly upgrade him, but not before telling Watson that the Memorandum is in Japan and asking him to destroy it.
Following an explosion, and before losing consciousness, Watson witnesses a mysterious man taking the Memorandum, who reveals himself as Frankenstein's original creation, known as The One - still alive after 100 years and just as intelligent as a human.
Watson awakens aboard the USS Richmond heading for America, where he is treated by Hadaly and is asked along with Burnaby by Grant to help him defeat The One, who he believes is lashing out at humanity as vengeance for creating him.
Grant is killed by an exploding corpse, and Hadaly guides Watson and Friday to a sewer entrance that will take them to her safehouse before she and Burnaby briefly part ways.
He is taken to the Tower of London where his mind is analyzed by Charles Babbage and Frankenstein's preserved brain, which creates a stronger signal that causes more corpses to attack humans.
However, before he can complete the ritual, Burnaby damages Charles Babbage, forcing The One to return to his own body, and with Friday's help, Watson manages to permanently seal The One into the Memorandum, defeating him and destroying the Tower.