His crowning achievement was the creation of Counter-Earth; however, this was viewed as little more than a trivial matter by the Beyonders, who captured the planet for display in a cosmic museum of curiosities.

[2] The High Evolutionary is revealed to have survived his suicide attempt, and has rededicated himself to guiding and enhancing the evolution of humanity so that his race may one day be supreme to all others, including the Beyonders.

To this end he initiates several concurrent efforts to accelerate human evolution and eliminate perceived threats to mankind's genetic purity.

When they capture Magma from Nova Roma, the inner circle of the Hellfire Club and the New Mutants storm the Purifier base in Wyoming to rescue her.

Seeking to retaliate against the ones who disrupted his drug trade, the Kingpin learns about the High Evolutionary's scheme and allows the information to reach Spider-Man and Daredevil.

Garokk and the Evolutionary succeed in restoring the Savage Land, and the survivors of Terminus's original attack return from the extradimensional realm in which they had taken refuge.

[9] The Exterminators attempt to seal off the Nexus of All Realities in the Everglades to prevent extradimensional entities from polluting humanity's genetic stock.

One such entity known as Ylandris takes possession of Cecilia Cardinale, transforming her into Poison in order to stop the Evolutionary's plan, while Spider-Man and the Man-Thing defeat the Exterminators.

Coincidentally, estranged Avengers Moon Knight, Tigra, and Mockingbird happen upon the High Evolutionary's citadel in the Savage Land and rescue Foster, who recovers his Giant-Man powers.

[11] Before completion of the genetic bomb, the High Evolutionary sends Gatherers to capture a rogue clone of Gwen Stacy for further study, while he visits the Young Gods.

[12] The Evolutionary's researchers reassemble Jocasta, who immediately turns on her captors and attempts to contact the East Coast Avengers about the genetic bomb.

Both Hercules and the High Evolutionary are apparently destroyed in the battle, leaving the Avengers free to stop the genetic bomb and save the world.

[13] Each chapter of the crossover features a short back up strip titled "The High Evolutionary" which was written by Mark Gruenwald with pencil art by Paris Cullins and Ron Lim.

In the course of the story, it is revealed that the High Evolutionary received help from a mysterious benefactor, who provided him with the secrets of the human genetic code and access to Moloids to build his base on Wundagore Mountain.