The comic was created by writer Simon Oliver and artist Tony Moore and follows the employees of the Bug-Bee-Gone extermination company.

The Exterminators initial incarnation was a TV pitch and pilot outline[2] as writer Simon Oliver was working in the film industry at the time.

Henry lives in an apartment with his girlfriend Laura, a high level employee of Ocran Industries, manufacturers of chemical products.

Henry is out of prison, and after AJ overdoses on Draxx, the insect-killing gel that Bug-Be-Gone uses, the police try to solve a break-in at the extermination company.

Sal, the head scientist at Bug-Be-Gone, discovers that insects mutate after prolonged exposure to Draxx, skipping their evolution up several generations.

One of the apartment's mutated cockroaches finds the resurrected AJ, now calling himself CJ, who is actually a reborn Egyptian pharaoh who worships insects.

CJ murders one of the employees of Bug-Be-Gone to prove himself to the mutant roach leaders, as fruit from Madagascar infested with Hisser cockroaches is shipped to America.