The Four-Chambered Heart is a 1950 autobiographical novel by French-born writer Anaïs Nin, part of her Cities of the Interior sequence.

When Nin met Moré in 1936 his wife was an invalid, after having been a widely renowned exotic dancer, both in Europe and on Broadway, and the couple were impoverished and living in a basement.

Nin's relationship with Moré was full of passion, lust and sexual fury, which is reflected in the story of The Four-Chambered Heart.

She brought Moré with her and employed him in a printing press enterprise she started on her own, ultimately trying to rip apart the destructive cord to his wife and make him learn a craft of his own.

People create an illusion together and then it is disintegrated by reality.“[1] The remains of this destructive relationship is this novel, The Four-Chambered Heart, in which she tries to describe the anguish and the passion she felt in her decade-long relation with Moré.