[4] After Oz's November 2021 announcement that he would run as a Republican for the U.S. Senate seat in Pennsylvania, the show ceased production and aired its final episode on Friday, January 14, 2022.

A food-themed spin-off talk show, The Good Dish, filled the timeslot on most stations from January 17 through the end of the 2021–22 television season, with its final episode airing May 25, 2022.

[11] Beginning with season five, The Dr. Oz Show was recorded in the ABC Television Center East on the Upper West Side of Manhattan.

On December 13, 2021, Sony Pictures Television (SPT) confirmed that The Dr. Oz Show would air its final episode on Friday, January 14, 2022.

[5] The final program, which featured a discussion about shrinkflation and an interview with Maria Shriver, did not directly reference the show's end until the last segment, which was filmed in a different studio, in which Oz confirmed he was stepping aside due to his run for office, but expressed pride in how the series had, in his view, benefited viewers over its thirteen seasons.

[5] On March 9, less than two months after its launch, Deadline Hollywood reported The Good Dish would not be renewed in syndication beyond its initial partial season, with SPT exploring other cable or streaming outlets for the program.

However, he has been unsuccessful in convincing his former producers to bring it back, citing his highly controversial views after entering politics and a massive ratings drop after Oz announced his run for office.