ET during the Major League Baseball regular season and is hosted by Lauren Gardner with analysis from Xavier Scruggs, Ariel Epstein, and various guest analysts.

Off Base was announced as an addition to MLB Network's programming in April 2022, just after the 2021–22 Major League Baseball lockout and prior to the start of the 2022 season.

The show's direction was noted as being a part of MLB's efforts to address low viewership with younger audiences, particularly among Generation Z and Millennials.

A poll conducted by Seton Hall University three months prior to the debut of the show found that MLB viewership was declining, particularly among younger fans.

Former MLB first baseman Xavier Scruggs, baseball writer Hannah Keyser, and WFAN Radio sports radio host Keith McPherson joined the show as permanent analysts, with a fourth spot on the set left open for rotating guest analysts,[2] which have included former MLB catcher Anthony Recker and actress Ellen Adair.