It is a wild west-themed sequel to Give Me the Brain, and the fourth in the Friedey's series of games.
Players assume the role of zombies attempting to rob a speeding train full of brains.
As the players move forward through the carriages, new ones are added and old ones fall off, giving a varied and changing game board.
[1] The Great Brain Robbery was the first board game to come in a sturdy cardboard box.
[citation needed] In 2001, The Great Brain Robbery won the Origins Award for Best Science Fiction or Fantasy Board Game 2000.