Webster wrangled with the nationalists Clay and Calhoun on post-war issues such as the chartering of the Second Bank of the United States and the Tariff of 1816.
The three would remain in the Senate until their deaths, with exceptions for Webster and Calhoun's tenures as Secretary of State and Clay's presidential campaigns in 1844 and 1848.
With each one representing the three major sections of the United States at that time and their respective mindsets (the Western settlers, the Northern businessmen, and the Southern slaveholders), the Great Triumvirate was responsible for symbolizing the opposing viewpoints of the American people and giving them a voice in the government.
The debates leading to the Compromise of 1850 were the last major contribution of the three as they were eclipsed by a new generation of political leaders like Jefferson Davis, William H. Seward, and Stephen A. Douglas.
Calhoun was so ill at the time of the Senate debate on the Compromise that he was unable to deliver his fiery speech opposing it, instead having it read for him by James Mason while he sat in the chamber.