Maria, it stars Sylvia Sanchez, Nonie Buencamino, Andi Eigenmann, Dimples Romana, Arron Villaflor, Matt Evans, Joshua Garcia, and Ruby Ruiz.

Despite the fact that they love each other, Gloria is forced under duress by her father to marry Andres Alegre (Junjun Quintana), the town mayor's nephew who raped her.

Through the years, Gloria (Sylvia Sanchez) is a loving and selfless mother to Amanda (Dimples Romana), Andrei (Matt Evans), Paeng (Arron Villaflor), and Lizelle (Andi Eigenmann).

As her illness progresses, Gloria attempts to bring back the love her family once had for each other; however, it becomes more difficult as she races against time while trying to gather her memories before they are completely wiped out.

The Greatest Love was reported to replace the soon-to-be concluded My Super D on July 18, 2016,[17] but was postponed (and moved to later date) because of Pinoy Big Brother: Mga Kwento ng Dream Team ni Kuya.