[2] Updates are added by its clinical editors through advice and recommendations from the Joint Committee on Vaccination and Immunisation (JCVI), as accepted by the Secretaries of State.

[3][4] Part one, titled "principles, practice and procedures", has 12 chapters which include how vaccines work, storage and distribution, vaccine safety and adverse events, immunisation schedule and immunisation of healthcare and laboratory staff.

[1] The 2006 edition incorporated the then new vaccines for meningococcal group C and pneumococcal infections, included the cessation of the school's BCG programme and the introduction of the Hib-MenC booster at 12 months of age.

[5][7] As of 2021, the online version stays divided into two parts, in the same way as the 2006 edition, and includes updates on shingles and COVID-19.

[6][8][9] According to Andrew Pollard, The Green Book should be "bookmarked" in all child clinics and notes that similar information can be obtained from the US Centers for Disease Control and Prevention website.