Greg Wilson got his start in comedy when Phil Larsson heard of him, and added him as a member of the Dallas improv theater group Ad-Libs.
As an actor, Wilson has appeared in television series such as Bones, Ugly Betty, and Modern Family, usually in small, episodic roles, as well as commercials for Heineken[11] and Toyota, among other brands.
In 2008, Wilson landed a starring role in the romantic comedy film The Hottie and the Nottie, opposite Paris Hilton and Joel David Moore.
Notable voice acting roles include the character JD O'Toole in the video game Grand Theft Auto: Liberty City Stories and the eponymous Mr. Two in the animated Nickelodeon pilot Charlie and Mr. Two.
On April 26, 2013, /Film writer Peter Sciretta claimed Wilson had been publicly accused of joke theft during a taping of America's Got Talent.