The fourth season of Desperate Housewives, an American television series created by Marc Cherry, premiered on September 30, 2007, on ABC.

Filming for the series was interrupted by the 2007–2008 Writers Guild of America strike in November 2007, after production on the two-episode tornado storyline wrapped.

The series is narrated by Brenda Strong, who portrays the deceased Mary Alice Young, as she observes from beyond the grave the lives of the Wisteria Lane residents and her former best friends.

Marcia Cross portrayed Bree Hodge, married for the second time and faking pregnancy in an attempt to protect her daughter.

Ricardo Antonio Chavira portrayed Carlos Solis, now divorced from Gabrielle but still in love with her while involved in a relationship with Edie.

Kyle MacLachlan portrayed Orson Hodge, Bree's second husband and the man that ran over Mike in the second season finale.

Lyndsy Fonseca was cast in the new role of Dylan Mayfair, Katherine's daughter and part of the season's mystery.

Rachel Fox was promoted to regular after guest starring in several episodes in the previous season as Kayla Huntington Scavo, Tom's mischievous daughter and the result of an affair he had before meeting Lynette.

Kathryn Joosten portrayed Karen McCluskey, one of the most prominent residents of Wisteria Lane, Richard Burgi appeared as Karl Mayer, Susan's ex-husband who is also married again, Pat Crawford Brown played elderly neighbor Ida Greenberg, whereas Tuc Watkins and Kevin Rahm made their debut in this season respectively as Bob Hunter and Lee McDermott, a gay couple from Chicago who move to the lane.

Part of Gabrielle's storyline were John Slattery playing Victor Lang, Gabrielle's new husband and the mayor of Fairview, Mike Farrell in the role of Milton Lang, Victor's father, Jeff Doucette portraying Father Crowley, priest at the local Catholic church, Justine Bateman playing Ellie Leonard, a drug dealer who rents a room in the Solises' house, and Jesse Metcalfe reappearing as John Rowland, Gabrielle's ex-lover and former gardener.

Additionally, Gale Harold was introduced as Susan's new lover Jackson Braddock during the five-year jump featured at the end of the season.