The Gun in Betty Lou's Handbag is a 1992 American screwball comedy film directed by Allan Moyle and produced by Scott Kroopf.

It stars Penelope Ann Miller, Eric Thal, William Forsythe, Cathy Moriarty and Alfre Woodard.

Rock and roll recording pioneer Cordell Jackson played a bit part as "Bathroom Woman".

A criminal kingpin is killed in cold blood, and Betty Lou happens to find the murder gun.

[2] The Austin Chronicle gave it two stars: "The cast shines in The Gun in Betty Lou's Handbag; watching these performers, you know this movie would have made for an inspired farce, given better writing and direction.