[1] The show was hosted by two life-size female puppets named Honey and Sis: Honey (voiced by Udana Power) is a 19-year-old willowy tall blond who fancies herself a gifted performer, while her 17-year-old red-headed sister Sis (voiced by Wendy McKenzie) is actually the talented one.
[2] On each episode, Honey and Sis sang, danced and participated in comedy sketches as "The Disco of Life", a soap opera parody where they interacted with people at a disco, and "The Truth Tub" where they relaxed in a hot tub and parodied TV shows such as Laverne & Shirley and Three's Company.
The guest stars during the five-week period included Melissa Sue Anderson, Tom Bosley, Gary Burghoff, Charo, Leif Garrett, Melissa Gilbert, Dan Haggerty, Linda Lavin, Peter Lupus, Gavin MacLeod, Tony Randall, Connie Stevens, The Sylvers, Twiggy, Abe Vigoda, Betty White and Anson Williams.
Costumed actors impersonating Hanna-Barbera cartoon characters such as Yogi Bear, Huckleberry Hound and Snagglepuss (all voiced by Daws Butler) made cameo appearances.
Although only scheduled for a five-week test run, The Hanna-Barbera Happy Hour failed in the ratings as it competed with ABC's Welcome Back, Kotter and What's Happening!!