The event results in a supernatural reversal of time, symbolized by the fast, counter-clockwise movement of hands on the house's many clocks.
An elderly couple, Vittorio and Sara Corsini, live in a rambling country house filled with different clocks.
She eventually discovers the dead bodies of a money-grabbing nephew and his wife lying preserved in open coffins in the wine cellar.
Meanwhile, three hoodlums, Diana, Tony and Paul are driving through the area and decide to rob the house after receiving a tip-off from a grocery store owner in a nearby town about the wealth it supposedly contains.
A bloodbath ensues with Sara accidentally getting shot, Peter getting killed by Paul, and Vittorio attacking Tony, forcing Diana to shoot him dead.
He discovers that the bloodstains in the dining room where the killings took place disappeared, and then sees the bodies lying back where they had fallen.
Hearing the gunshot, Diana and Tony get dressed, rush downstairs and see the old couple reanimate and advance towards them.
As the couple run across the grounds, now in daylight with the clocks in full reverse, Tony is pulled into a shallow grave by Maria's corpse.
Maria then confronts the elderly couple in the wine cellar with murdering their nephew and his wife to remove them as their rightful heirs to the estate.
A dead cat they picked up on the road earlier revives and attacks them, forcing Tony to drive their car off a cliff and killing them all again.
The House of Clocks is one of four films made for the Italian television series La case maledette (transl.
[5] Robert Firsching of AllMovie called the film "a credible addition to the director's oeuvre – sometimes reminiscent of Dolls or Pete Walker's creepy punishment gothics (Frightmare, House of Whipcord, etc.)