The series starred the various dissociative identities, or "alters," of Bruce Banner as they grapple with the discovery that gamma-irradiated beings such as the Hulk are unable to die.

[5][6][7] After spawning numerous one-shots by various creative teams and a spinoff miniseries starring Gamma Flight, the series concluded with issue #50 in October 2021.

[8] The series begins in the aftermath of the "No Surrender" storyline in Avengers, with the Hulk returning from his death at the hands of Hawkeye during the Civil War II crossover event.

Brian Banner, Hulk's abusive father, and The Leader, his longtime nemesis, both plan to use the realm for their own nefarious goals.

Matt Lune of Multiversity Comics called the first issue "extremely well done," praising the reimagining of the Hulk as "a terrifying figure, with a grim, twisted, toothy smile, piercing stare and distinctly disturbing eloquence.

Following this, a 2018 political cartoon resurfaced in which the then-Brazilian presidential candidate Jair Bolsonaro was allegorically depicted as an “Independence Dragoon” (a member of a historical Brazilian military unit) fighting political opponents (including former presidents Luiz Inácio Lula da Silva, Dilma Rousseff and Michel Temer) in the shape of monstrous rats.