[4] According to the show's producers, "The Infinite Mind" looked at "how the brain works, and why it sometimes does not, covering mental health, neuroscience and the mind/body connection from scientific, cultural and policy perspectives.

In the two months following the September 11th attacks, The Infinite Mind produced a series of five programs on the mental health impact of the terrorism, which were first national programs to examine the mental health impact of the September 11th attacks, as well as two live "State of Mind" broadcasts that featured guests Tipper Gore, Rosalynn Carter, Al Franken, Judy Collins, David Straithairn, Surgeon General David Satcher and Marian Wright Edelman, among others.

The program featured the leading experts in the field of neuroscience, mental health and the mind such as Steven Pinker, Department of Brain and Cognitive Sciences at MIT.

In addition to world-leading scientific researchers and medical professionals, The Infinite Mind featured subjects of interest to a broad listening audience with celebrity guests including author John Updike; actors Carrie Fisher, Stanley Tucci, Anthony Edwards, Mercedes Ruehl, Margot Kidder and David Straithairn; comedians Richard Lewis and Lewis Black; the Firesign Theater; author William Styron and his wife Rose Styron; baseball batting champ Wade Boggs; former First Lady Rosalynn Carter; documentary filmmaker Ric Burns; television pioneer Norman Lear; business journalist James Cramer; Tipper Gore; Children’s Defense Fund founder Marian Wright Edelman; and live performances and discussions with musicians including Aimee Mann, Jessye Norman, Judy Collins, Suzanne Vega, Janis Ian, Laurie Anderson, Cowboy Junkies, Loudon Wainwright III, Philip Glass, and Emanuel Ax, and the casts of the Broadway hits Avenue Q and Wicked.

[9] For "The Infinite Mind," Lichtenstein Creative Media produced the first ever concert and live radio broadcasts from Second Life in August 2006, with singer Suzanne Vega, author Kurt Vonnegut who appeared in avatar form, Internet visionary Howard Reingold, and design guru John Maeda.

[11] On November 21, 2008, The New York Times reported that the staff of Senator Charles Grassley had "uncovered"[6] the fact that host Fred Goodwin had received "at least $1.3 million from 2000 to 2007 giving marketing lectures for drugmakers, income not mentioned on the program", largely speaking fees for talks to clinicians.