A TV tie-in novel based on the script of the pilot episode was written by Michael Jahn and published by Fawcett Gold Medal in 1975.

Wells, the pilot film depicts Daniel Westin working for a company called the Klae Corporation, which is doing experiments in teleportation.

He goes to his friend, Dr. Nick Maggio (Henry Darrow), a skilled plastic surgeon who creates a disguise for him in the form of a face mask and a pair of gloves using a special material called Dermaplex that has the same properties as human skin, which enable Westin to appear in public.

By the conclusion of the pilot, the process's lack of stability renders it effectively useless for commercial or military applications, and the Klae Corporation is persuaded to re-employ him in his research capacity despite his condition, and thus the series begins from this point.

The series was lighter and more humorous, featuring invisibility-related gags and scenarios (in the case of the latter, many of these were depicted in the opening title sequence—such as a telephone receiver rising unsupported off its hook and a Jeep driving itself, to name but two), and ignoring the tragic side of Westin's predicament.

Another difference is in the area of casting; in the pilot, Jackie Cooper portrayed Westin's superior, Walter Carlson, but for the series, the role was recast with Craig Stevens playing the part.

Wells' Invisible Man, the episodes featured sequences of the camera taking on Westin's point of view, showing whoever and/or whatever the character himself was seeing at the time.

However, the show was canceled after one season due to low ratings before the underlying arc of Westin curing his invisibility and returning to normality could be resolved.