The Journal of Infectious Diseases is a peer-reviewed biweekly medical journal published by Oxford University Press on behalf of the Infectious Diseases Society of America.

It covers research on the pathogenesis, diagnosis, and treatment of infectious diseases, on the microbes that cause them, and on immune system disorders.

Cynthia Sears, an expert on gut infections, was appointed editor-in-chief in 2023.

[1] The journal was established in 1904 and was a quarterly until 1969 when it became a monthly.

From 1904 to 2011, the journal was published by the University of Chicago Press.