Wren Peterson is a physician and activist working in West Africa with the organization Doctors of the World that her late father started many years ago.

In 2003, Wren meets Miguel, a handsome surgeon who has also devoted himself to treating people from impoverished and war-torn sections of the world.

[10] The reception for The Last Face at Cannes was very negative and The Sydney Morning Herald reported that the film was booed during its screening.

The site's critics' consensus reads: "The Last Face's noble intentions are nowhere near enough to carry a fundamentally misguided story that arguably demeans the demographic it wants to defend.

[14] The Hollywood Reporter panned the film, writing "A backdrop of Third World atrocity, suffering and merciless human-rights violations serves as the canvas for a faux-profound Hollywood love story in Sean Penn's stunningly self-important but numbingly empty cocktail of romance and insulting refugee porn, The Last Face.