The series interviews DEA agents and witnesses to Camarena's death who state that he was murdered by Mexican drug lords, with the complicity of the CIA.
[1] The docuseries recounts the story of DEA Agent Kiki Camarena's investigation of Mexican cartel drug lords including Miguel Angel Felix Gallardo, Ernesto Fonseca Carrillo and Rafael Caro Quintero, his death at the hands of drug lords and the CIA, and the DEA relations that followed Camarena's death.
"[2] According to the Florida-based CE Noticias Financieras, The Last Narc "is notable" for approaching the story of Camarena's death beyond the ordinary patriotic narratives of the US and Mexican governments.
"[8] David Hathaway, a DEA agent who worked in South America alongside Phil Jordan and Mike Holm, endorsed the series.
[9][10] On December 21, 2020 James Kuykendall, former chief of a DEA field office in Mexico, sued Amazon and the makers of the documentary, alleging that it depicted him as complicit in the murder of Kiki Camarena.