The characters and plot elements borrow from works of writers such as Jules Verne, Sir Arthur Conan Doyle, Bram Stoker, H. G. Wells and Robert Louis Stevenson.
As the other man rushes off to tell the authorities, Mina drags Allan through the busy streets towards the docks, where Nemo's submarine, the Nautilus, emerges from the sea.
When the League return to London, Bond sets them their next task: going undercover at a girls' school to investigate three separate cases of sexless conception.
Late at night, Mina catches an unseen force sexually assaulting one of the girls, Pollyanna, and throws a tin of paint over it, making the entity partly visible.
The League successfully apprehend the "Holy Spirit", which is actually Hawley Griffin, the Invisible Man, and take him to their new headquarters within the secret annexe of the British Museum.
With the League fully assembled, Bond gives them the task of recovering a stolen supply of Cavorite from a crime lord referred to as "The Doctor" (an alias for Fu Manchu, which name the comic was not allowed to use, for trademark reasons).
He explains that Britain was secretly planning a Moon landing to coincide with the turn of the 20th century celebrations, supervised by Professor Selwyn Cavor and using Cavorite to power and levitate heavier-than-air machines.
Mina and Griffin question Quong Lee (a storyteller from books by Thomas Burke), who reveals that The Doctor is indeed operating within the area, but only gives them information in the form of a cryptic riddle: "The waters lap beneath the heavenly bridge.
Mina believes The Doctor has stolen the Cavorite for some nefarious purpose, and suspects that he is building an aerial war machine in the unfinished Rotherhithe Tunnel.
She and Allan return to the Limehouse district to investigate activity around the abandoned Rotherhithe Tunnel, and eventually find a large cavern where The Doctor's airship (the "dragon" from Quong Lee's riddle) is being constructed.
Jekyll turns into Mr Hyde and starts slaughtering the guards, while Allan and Mina sneak into the ship, locate the Cavorite engine and steal it.
However, Moriarty survives his fall into the water below (though his spine and right arm are broken and heal in a deformed state), and is rescued by Campion Bond and Colonel Sebastian Moran.
Griffin returns to the Nautilus and informs the league of what he's discovered, and that Moriarty plans to bomb London's East end and destroy what remains of The Doctor's criminal empire.
This ad caused DC executive Paul Levitz to order the entire print run destroyed and reprinted with the offending advertisement edited.