In the aftermath of the events of the novel Dracula, a now disgraced and divorced Mina Harker (née Murray) is recruited by Campion Bond on behalf of British Intelligence head "M" and asked to assemble a league of other extraordinary individuals to protect the interests of the Empire.
Together with Captain Nemo, Mina travels to Cairo to locate Allan Quatermain, then on to Paris in search of Dr. Jekyll; finally in London she forcibly recruits Hawley Griffin, The Invisible Man, who completes this incarnation of the League.
Meeting with Professor Cavor, the League is sent against Fu Manchu in his Limehouse lair, who has stolen the only known sample of cavorite and plans to use it to build an armed airship, against which Britain would have little defence.
Mycroft Holmes replaces Moriarty as the League's employer, and the extraordinary individuals are given the task of remaining in the service of the Crown, awaiting England's call.
Griffin leaves the League under cover of invisibility to form an alliance with the invaders before betraying it outright, stealing plans for the defence of London as well as physically and emotionally assaulting Mina.
Events take place after the fall of the Big Brother government from Nineteen Eighty Four (the in-story explanation for this apparent date-shift is that Orwell's book was published in 1948).
The story itself sees Mina Harker and Allan Quatermain—now immortal after bathing in the fire of youth from She—on their quest to recover the Black Dossier itself (a confessed MacGuffin), in a metafictional unravelling of the secret history of the now-disbanded League of Extraordinary Gentlemen.
Initially intended to be accompanied by a 45-rpm record featuring songs referenced in the plot, this addition was shelved ostensibly to be included as an incentive with the 'Absolute Edition', and ultimately dropped entirely—to the chagrin of the author/singer.
[2] Chapter one is set against a backdrop of London, 1910, with Halley's Comet passing overhead, the nation prepares for the Coronation of George V, and far away on his South Atlantic island, the scientist-pirate Captain Nemo is dying.
In the bowels of the British Museum, Carnacki the ghost-finder is plagued by visions of a shadowy occult order who are attempting to create something called a Moonchild, while on London's dockside the most notorious serial murderer of the previous century has returned to carry on his grisly trade.
Starting to buckle from the pressures of the twentieth century and the weight of their own endless lives, Mina and her companions must nevertheless prevent the making of a Moonchild that might well turn out to be the Antichrist.
[6] The plot is described as follows: "Opening simultaneously in the panic-stricken headquarters of British Military Intelligence, the fabled Ayesha's lost African city of Kor and the domed citadel of ‘We’ on the devastated Earth of the year 2996, the dense and yet furiously-paced narrative hurtles like an express locomotive across the fictional globe from Lincoln Island to modern America to the Blazing World; from the Jacobean antiquity of Prospero's Men to the superhero-inundated pastures of the present to the unimaginable reaches of a shimmering science-fiction future.
The first League was established at the behest of England's Queen Gloriana recommending that Italian sorcerer Prospero and his squire Orlando found a group of extraordinary individuals after her death who would operate independently of the government.
This League collapsed in 1690 when the unwilling extradimensional traveler Christian found the heavenly realm he had been searching for in order to lead him to his home, the Blazing World.
Having tried (and failed) to avert disaster at George V's coronation in 1910 and battled their French equivalents in 1913 Paris, the end of Mina's Second League ostensibly came about with the outbreak of World War I, during which A. J. Raffles was killed.
In 1913, responding to psychic warnings received by Thomas Carnacki, Mina's second League traveled to the Paris Opera House to thwart a scheme of Les Hommes Mystérieux, where the two groups fought.
Fraught by tensions and prone to failure from the outset, this team only went on one mission together—battling pirate-slaver James Soames and Italian criminal mastermind Count Zero (both from Frank Richards's Greyfriars School series)—before disbanding.
In 1958, not long after the Big Brother government's fall, the two surviving Leaguers (Mina Murray and Allan Quatermain) returned to London and broke into British Intelligence headquarters, stealing the Black Dossier that contained details of all the League's incarnations.
Eventually successful, Mina and Allan departed to the Blazing World once more, far beyond the reach of the shadowy agencies pursuing them, where they were reunited with Orlando, Prospero, Fanny Hill, and many other previous members of the League.
[8] In the same year, MI5 assembled its own super team, which came into conflict with Mina's Seven Stars: By 1969 Wilhelmina Murray, Allan Quatermain and Orlando are summoned by Prospero in order to investigate the recent activities of Oliver Haddo's sect.
By 2009, the League is defunct, until Orlando, recently discharged from the British Army, is tasked by Prospero to eliminate the Antichrist, and is reunited with Mina, and a now homeless and once-again drug addicted Allan who at first refuses to join them.