It was cancelled and replaced with America Live with Megyn Kelly.

This show originally aired as a one-hour program when it debuted on September 25, 2006.

Compared to the network's main news programming, half the program aired from one of the network's control rooms, the other half airing from Studio D. The second half also featured a panel, named the A-list, with a special guest panelist, labeled the Wildcard.

Hosted by Martha MacCallum, the program replaced DaySide, which ended on September 22, 2006, due to its hosts leaving the network to begin The Morning Show with Mike and Juliet for Fox.

[1] On May 28, 2009, The Live Desk launched in high definition with new graphics, new music, and the use of HD ready Studio J.