Just like with Nickelodeon's first live NFL telecast on January 10, 2021 (the NFC Wild Card playoff game between the Chicago Bears and New Orleans Saints), these highlights are flavored with digital, comic strip-like animation[15] such as white smoke, green slime,[16] and blue lightning.

The weekly winner of "Celebrity Pick Party" reserved the right to wear the "Slime Chain", an oversized NFL Slimetime logo studded in colored rhinestones.

Following Nickelodeon's first live NFL broadcast, the network brought back the NVP award for each episode, based on a player's performance the previous week and announced by Lincoln Loud (voiced by Asher Bishop, then[when?]

[28] Lincoln Loud briefly returned as the NVP announcer for the Pro Bowl, but using the same voice over as Week 4 and slightly changing the accompanying animation.

[31] Other winners during the 2021 season have included the participating quarterbacks in Super Bowl LV, Tom Brady[32] and Patrick Mahomes,[33] and Justin Tucker, whose record-setting 66-yard field goal led the Baltimore Ravens to victory in Week 3.